Live bibliography data from NCBI and PubMed.

2026 Feb 26

Insights and modulation of RNA polymerases-dependentR-loop and dsRNA inFanconi anemia hematopoietic stem cells

Hashimoto M, Feng X, Bai J, Zeng H, Li T, Li J, Umemoto T, Andreassen PR, Huang G

JCI insight · DOI 10.1172/jci.insight.192126 · PMID 41746738

2026 Feb 2

Luspatercept ameliorates disease phenotype and complications in the Townes mouse model of sickle cell disease

Sezaki M, Li T, Pan M, Wang Z, Bai J, Horowitz JG, Xu JZ, Huang G

The Journal of clinical investigation · DOI 10.1172/JCI197706 · PMID 41623180

2025 Nov 7

The RNA N(6)-methyladenosine methylome coordinates long non-coding RNAs to mediate cancer drug resistance by activating PI3K signaling

Tan Y, Zhou C, Bian S, Bian H, Ren Y, Walter W, Pang J, Cheng T, Wang H, Yang Y, Guo W, Zhang L, Al-Kali A, Litzow MR, Han X, Yu J, Yang R, Huang G, Hoermann G, Tse W, Liu S

Cell death & disease · DOI 10.1038/s41419-025-08045-6 · PMID 41203598

2025 Sep

Aberrant splicing of CHEK1 is a driver of megakaryocytic dysplasia in U2AF1(S34F) mutant myelodysplastic neoplasms

Zhang W, Li B, Liu J, Yan Y, Yang L, Qin T, Xu Z, Sun Q, Jia Y, Wang H, Huang G, Wang H, Shi L, Zhou J, Xiao Z

Leukemia · DOI 10.1038/s41375-025-02684-6 · PMID 40652060

2025 Aug 1

Mitophagy's impacts on cancer and neurodegenerative diseases: implications for future therapies

Huang J, Pham VT, Fu S, Huang G, Liu YG, Zheng L

Journal of hematology & oncology · DOI 10.1186/s13045-025-01727-w · PMID 40750884

2025 Jun

Super-resolution imaging informed scRNA sequencing analysis reveals the critical role of GDF15 in rejuvenating aged hematopoietic stem cells

Shi Z, Zhang X, Yang H, Zheng X, Niu M, Zhang Y, Yuan P, Wei W, Huang G, Fang R, Chen L

Blood science (Baltimore, Md.) · DOI 10.1097/BS9.0000000000000236 · PMID 40416726

2025 May 30

Integrated Computational and Functional Screening Identifies G9a Inhibitors for SETD2-mutant Leukemia

Zhang Y (张亚), Xia M (夏梦芳), Yi Z (易真伊), Sui P (岁品品), He X (何旭东), Wang L (王丽萍), Chen Q (陈祺仪), Zhu HH (主鸿鹄), Huang G (黄刚), Wang QF (王前飞)

Genomics, proteomics & bioinformatics · DOI 10.1093/gpbjnl/qzaf035 · PMID 40300107

2025 Apr 28

Epigenetic silencing of DNA sensing pathway by FOXM1 blocks stress ligand-dependent antitumor immunity and immune memory

Timilsina S, Huang JY, Abdelfattah N, Medina D, Singh D, Abdulsahib S, Subbarayalu P, Do TP, Venkata PP, Nirzhor S, Prochnau J, Bhandari M, Zheng S, Chen Y, Huang G, Mukherjee N, Hromas R, Sung P, Kaklamani V, Vadlamudi R, Zhang N, Rao MK

Nature communications · DOI 10.1038/s41467-025-59186-3 · PMID 40295473

2025 Apr

Age-Dependent Bi-Phasic Dynamics of Ly49(+)CD8(+) Regulatory T Cell Population

Srinivasan S, Mishra S, Fan KK, Wang L, Im J, Segura C, Mukherjee N, Huang G, Rao M, Ma C, Zhang N

Aging cell · DOI 10.1111/acel.14461 · PMID 39696807

2025 Jan 21

Sexual dimorphism in the mouse bone marrow niche regulates hematopoietic engraftment via sex-specific Kdm5c/Cxcl12 signaling

Cui X, Hou L, Yan B, Liu J, Zhang C, Sui P, Tong S, Luchsinger L, Mendelson A, Zhou D, Yang FC, Zhong H, Liang Y

The Journal of clinical investigation · DOI 10.1172/JCI182125 · PMID 39836478

2025 Jan 9

Loss of Cpt1a results in elevated glucose-fueled mitochondrial oxidative phosphorylation and defective hematopoietic stem cells

Li J, Bai J, Pham VT, Hashimoto M, Sezaki M, Shi Q, Jin Q, He C, Armstrong A, Li T, Pan M, Liu S, Luan Y, Zeng H, Andreassen PR, Huang G

The Journal of clinical investigation · DOI 10.1172/JCI184069 · PMID 39786963

2024 Dec 4

The development and application of chimeric antigen receptor natural killer (CAR-NK) cells for cancer therapy: current state, challenges and emerging therapeutic advances

Yao P, Liu YG, Huang G, Hao L, Wang R

Experimental hematology & oncology · DOI 10.1186/s40164-024-00583-7 · PMID 39633491

2024 Sep 27

The Laws of Attraction: Chemokines as Critical Mediators in Cancer Progression and Immunotherapy Response in Bladder Cancer

Hassouneh Z, Kim ME, Bowman N, Rao M, Zhang N, Huang G, Svatek RS, Mukherjee N

Cancers · DOI 10.3390/cancers16193303 · PMID 39409924

2024 May

Long-term benefits of hematopoietic stem cell-based macrophage/microglia delivery of GDNF to the CNS in a mouse model of Parkinson's disease

Ge G, Sivasubramanian BP, Geng BD, Zhao S, Zhou Q, Huang G, O'Connor JC, Clark RA, Li S

Gene therapy · DOI 10.1038/s41434-024-00451-3 · PMID 38627469

2024 Feb 22

Ectopic expression of the transcription factor ONECUT3 drives a complex karyotype in myelodysplastic syndromes

Luo Y, Feng X, Lang W, Xu W, Wang W, Mei C, Ye L, Zhu S, Wang L, Zhou X, Zeng H, Ma L, Ren Y, Jin J, Xu R, Huang G, Tong H

The Journal of clinical investigation · DOI 10.1172/JCI172468 · PMID 38386414

2024

Into the storm: the imbalance in the yin-yang immune response as the commonality of cytokine storm syndromes

Armstrong A, Tang Y, Mukherjee N, Zhang N, Huang G

Frontiers in immunology · DOI 10.3389/fimmu.2024.1448201 · PMID 39318634

2023 Aug 10

Food for thought (and CML survival)

Sezaki M, Huang G

Blood · DOI 10.1182/blood.2023021051 · PMID 37561542

2023 Jul 3

Exposure to microbial products followed by loss of Tet2 promotes myelodysplastic syndrome via remodeling HSCs

Yokomizo-Nakano T, Hamashima A, Kubota S, Bai J, Sorin S, Sun Y, Kikuchi K, Iimori M, Morii M, Kanai A, Iwama A, Huang G, Kurotaki D, Takizawa H, Matsui H, Sashida G

The Journal of experimental medicine · DOI 10.1084/jem.20220962 · PMID 37071125

2023 Jun 13

A critical role of RUNX1 in governing megakaryocyte-primed hematopoietic stem cell differentiation

Wang C, Tu Z, Cai X, Wang W, Davis AK, Nattamai K, Paranjpe A, Dexheimer P, Wu J, Huang FL, Geiger H, Huang G, Zheng Y

Blood advances · DOI 10.1182/bloodadvances.2022008591 · PMID 36661340

2023 Mar

Runx1/3-driven adaptive endoplasmic reticulum stress pathways contribute to neurofibromagenesis

Na Y, Hall A, Yu Y, Hu L, Choi K, Burgard JA, Szabo S, Huang G, Ratner N, Wu J

Oncogene · DOI 10.1038/s41388-023-02620-x · PMID 36759572

2023 Jan 11

Repurposing immunosuppressants for antileukemia therapy

Sezaki M, Huang G

EMBO molecular medicine · DOI 10.15252/emmm.202217042 · PMID 36453114

2023

Editorial: Novel perspectives on the NLRP3 inflammasome

Liang Y, Hua KF

Frontiers in immunology · DOI 10.3389/fimmu.2023.1211385 · PMID 37251397

2022 Nov

Excessive IL-10 and IL-18 trigger hemophagocytic lymphohistiocytosis-like hyperinflammation and enhanced myelopoiesis

Tang Y, Xu Q, Luo H, Yan X, Wang G, Hu L, Jin J, Witte DP, Marsh RA, Huang L, Huang G, Zhou J

The Journal of allergy and clinical immunology · DOI 10.1016/j.jaci.2022.06.017 · PMID 35792218

2021 Dec 1

Tumor Microenvironment-Derived R-spondins Enhance Antitumor Immunity to Suppress Tumor Growth and Sensitize for Immune Checkpoint Blockade Therapy

Tang Y, Xu Q, Hu L, Yan X, Feng X, Yokota A, Wang W, Zhan D, Krishnamurthy D, Ochayon DE, Wen L, Huo L, Zeng H, Luo Y, Huang LF, Wunderlich M, Zhang J, Vivier E, Zhou J, Waggoner SN, Huang G

Cancer discovery · DOI 10.1158/2159-8290.CD-20-0833 · PMID 34193438

2021 Aug

Germline variants in UNC13D and AP3B1 are enriched in COVID-19 patients experiencing severe cytokine storms

Luo H, Liu D, Liu W, Wang G, Chen L, Cao Y, Wei J, Xiao M, Liu X, Huang G, Wang W, Zhou J, Wang QF

European journal of human genetics : EJHG · DOI 10.1038/s41431-021-00886-x · PMID 33867526

2021 Jun 28

Inflammation, epigenetics, and metabolism converge to cell senescence and ageing: the regulation and intervention

Zhu X, Chen Z, Shen W, Huang G, Sedivy JM, Wang H, Ju Z

Signal transduction and targeted therapy · DOI 10.1038/s41392-021-00646-9 · PMID 34176928

2021 Jun

Innate immune responses in RNA viral infection

Xu Q, Tang Y, Huang G

Frontiers of medicine · DOI 10.1007/s11684-020-0776-7 · PMID 33263837

2021 Jun

STAT3 and STAT5B mutations have unique distribution in T-cell large granular lymphocyte proliferations and advanced myeloid neoplasms

Qu S, Jia Y, Wang H, Ai X, Xu Z, Qin T, Pan L, Li B, Huang G, Gale RP, Xiao Z

Leukemia & lymphoma · DOI 10.1080/10428194.2020.1869964 · PMID 33410350

2021 May 14

Discovery of first-in-class inhibitors of ASH1L histone methyltransferase with anti-leukemic activity

Rogawski DS, Deng J, Li H, Miao H, Borkin D, Purohit T, Song J, Chase J, Li S, Ndoj J, Klossowski S, Kim E, Mao F, Zhou B, Ropa J, Krotoska MZ, Jin Z, Ernst P, Feng X, Huang G, Nishioka K, Kelly S, He M, Wen B, Sun D, Muntean A, Dou Y, Maillard I, Cierpicki T, Grembecka J

Nature communications · DOI 10.1038/s41467-021-23152-6 · PMID 33990599

2021 Mar 30

Protein S-nitrosylation regulates proteostasis and viability of hematopoietic stem cell during regeneration

Yi W, Zhang Y, Liu B, Zhou Y, Liao D, Qiao X, Gao D, Xie T, Yao Q, Zhang Y, Qiu Y, Huang G, Chen Z, Chen C, Ju Z

Cell reports · DOI 10.1016/j.celrep.2021.108922 · PMID 33789111

2021 Mar 19

VEXAS syndrome in myelodysplastic syndrome with autoimmune disorder

Huang H, Zhang W, Cai W, Liu J, Wang H, Qin T, Xu Z, Li B, Qu S, Pan L, Huang G, Gale RP, Xiao Z

Experimental hematology & oncology · DOI 10.1186/s40164-021-00217-2 · PMID 33741056

2021 Mar

Molecular and clinical features of myeloid neoplasms with somatic DDX41 mutations

Qu S, Li B, Qin T, Xu Z, Pan L, Hu N, Huang G, Peter Gale R, Xiao Z

British journal of haematology · DOI 10.1111/bjh.16668 · PMID 32307695

2021 Feb

Benzene induces rapid leukemic transformation after prolonged hematotoxicity in a murine model

Zhao J, Sui P, Wu B, Chen A, Lu Y, Hou F, Cheng X, Cui S, Song J, Huang G, Xing C, Wang QF

Leukemia · DOI 10.1038/s41375-020-0894-x · PMID 32503976

2021 Jan 5

Adaptive responses to mTOR gene targeting in hematopoietic stem cells reveal a proliferative mechanism evasive to mTOR inhibition

Fan C, Zhao C, Zhang F, Kesarwani M, Tu Z, Cai X, Davis AK, Xu L, Hochstetler CL, Chen X, Guo F, Huang G, Azam M, Tian W, Lu QR, Zheng Y

Proceedings of the National Academy of Sciences of the United States of America · DOI 10.1073/pnas.2020102118 · PMID 33443202

2021

Arsenic Dispensing Powder Promotes Erythropoiesis in Myelodysplastic Syndromes via Downregulation of HIF1A and Upregulation of GATA Factors

Fan T, Feng X, Yokota A, Liu W, Tang Y, Yan X, Xiao H, Wang Y, Deng Z, Zhao P, Wang M, Wang H, Ma R, Hu X, Huang G

The American journal of Chinese medicine · DOI 10.1142/S0192415X2150021X · PMID 33641653

2021 Jan

Dynamics of Blood Viral Load Is Strongly Associated with Clinical Outcomes in Coronavirus Disease 2019 (COVID-19) Patients: A Prospective Cohort Study

Chen L, Wang G, Long X, Hou H, Wei J, Cao Y, Tan J, Liu W, Huang L, Meng F, Huang L, Wang N, Zhao J, Huang G, Sun Z, Wang W, Zhou J

The Journal of molecular diagnostics : JMD · DOI 10.1016/j.jmoldx.2020.10.007 · PMID 33122141

2020 Sep

Elevated serum levels of S100A8/A9 and HMGB1 at hospital admission are correlated with inferior clinical outcomes in COVID-19 patients

Chen L, Long X, Xu Q, Tan J, Wang G, Cao Y, Wei J, Luo H, Zhu H, Huang L, Meng F, Huang L, Wang N, Zhou X, Zhao L, Chen X, Mao Z, Chen C, Li Z, Sun Z, Zhao J, Wang D, Huang G, Wang W, Zhou J

Cellular & molecular immunology · DOI 10.1038/s41423-020-0492-x · PMID 32620787

2020 Aug 14

Severe ineffective erythropoiesis discriminates prognosis in myelodysplastic syndromes: analysis based on 776 patients from a single centre

Huang H, Xu C, Gao J, Li B, Qin T, Xu Z, Ren S, Zhang Y, Jiao M, Qu S, Pan L, Hu N, Liu J, Cai W, Zhang Y, Wu D, Zhang P, Gale RP, Huang G, Zhou J, Shi L, Xiao Z

Blood cancer journal · DOI 10.1038/s41408-020-00349-4 · PMID 32801296

2020 Jul

Ruxolitinib in treatment of severe coronavirus disease 2019 (COVID-19): A multicenter, single-blind, randomized controlled trial

Cao Y, Wei J, Zou L, Jiang T, Wang G, Chen L, Huang L, Meng F, Huang L, Wang N, Zhou X, Luo H, Mao Z, Chen X, Xie J, Liu J, Cheng H, Zhao J, Huang G, Wang W, Zhou J

The Journal of allergy and clinical immunology · DOI 10.1016/j.jaci.2020.05.019 · PMID 32470486

2020 Mar

Mutational features of myelodysplastic syndromes with Auer rods reveal them are more akin to acute myeloid leukemia

Huang H, Qin T, Xu Z, Shi Z, Li B, Pan L, Hu N, Qu S, Huang G, Gale RP, Xiao Z

British journal of haematology · DOI 10.1111/bjh.16326 · PMID 31880320

2020 Feb 29

The Clinical, Molecular, and Mechanistic Basis of RUNX1 Mutations Identified in Hematological Malignancies

Yokota A, Huo L, Lan F, Wu J, Huang G

Molecules and cells · DOI 10.14348/molcells.2019.0252 · PMID 31964134

2020 Feb 29

The Role of RUNX1 in NF1-Related Tumors and Blood Disorders

Na Y, Huang G, Wu J

Molecules and cells · DOI 10.14348/molcells.2019.0295 · PMID 31940719

2020 Feb 3

DNMT3A mutants provide proliferating advantage with augmentation of self-renewal activity in the pathogenesis of AML in KMT2A-PTD-positive leukemic cells

Bera R, Chiu MC, Huang YJ, Huang G, Lee YS, Shih LY

Oncogenesis · DOI 10.1038/s41389-020-0191-6 · PMID 32015320

2020

Autophagy Gene Panel-Based Prognostic Model in Myelodysplastic Syndrome

Wang MJ, Liu WY, Wang XY, Li YM, Xiao HY, Quan RC, Huang G, Hu XM

Frontiers in oncology · DOI 10.3389/fonc.2020.606928 · PMID 33614490

2019 Dec 11

Mutant p53 drives clonal hematopoiesis through modulating epigenetic pathway

Chen S, Wang Q, Yu H, Capitano ML, Vemula S, Nabinger SC, Gao R, Yao C, Kobayashi M, Geng Z, Fahey A, Henley D, Liu SZ, Barajas S, Cai W, Wolf ER, Ramdas B, Cai Z, Gao H, Luo N, Sun Y, Wong TN, Link DC, Liu Y, Boswell HS, Mayo LD, Huang G, Kapur R, Yoder MC, Broxmeyer HE, Gao Z, Liu Y

Nature communications · DOI 10.1038/s41467-019-13542-2 · PMID 31827082

2019 Nov

Prognostic mutations in persons with isolated neutropenia myelodysplastic syndrome

Shi Z, Qin T, Xu Z, Li B, Huang H, Zhang H, Fang L, Pan L, Hu N, Qu S, Huang G, Gale RP, Xiao Z

Leukemia & lymphoma · DOI 10.1080/10428194.2019.1607324 · PMID 31056995

2019 Nov

SETD2 mutations confer chemoresistance in acute myeloid leukemia partly through altered cell cycle checkpoints

Dong Y, Zhao X, Feng X, Zhou Y, Yan X, Zhang Y, Bu J, Zhan D, Hayashi Y, Zhang Y, Xu Z, Huang R, Wang J, Zhao T, Xiao Z, Ju Z, Andreassen PR, Wang QF, Chen W, Huang G

Leukemia · DOI 10.1038/s41375-019-0456-2 · PMID 30967619

2019 Oct

Deletion of a flippase subunit Tmem30a in hematopoietic cells impairs mouse fetal liver erythropoiesis

Yang F, Huang Y, Chen X, Liu L, Liao D, Zhang H, Huang G, Liu W, Zhu X, Wang W, Lobo CA, Yazdanbakhsh K, An X, Ju Z

Haematologica · DOI 10.3324/haematol.2018.203992 · PMID 30819915

2019 Oct

Using circulating tumor DNA to monitor myelodysplastic syndromes status

Zhao P, Qin J, Liu W, Zhu Q, Fan T, Xiao H, Wang J, Huang G, Xiaomei H

Hematological oncology · DOI 10.1002/hon.2649 · PMID 31291480

2019 Aug 1

Identification and transcriptome analysis of erythroblastic island macrophages

Li W, Wang Y, Zhao H, Zhang H, Xu Y, Wang S, Guo X, Huang Y, Zhang S, Han Y, Wu X, Rice CM, Huang G, Gallagher PG, Mendelson A, Yazdanbakhsh K, Liu J, Chen L, An X

Blood · DOI 10.1182/blood.2019000430 · PMID 31101625

2019 Jul

Prognostic impact of red blood cell distribution width in myelodysplastic syndromes

Shi Z, Li B, Huang H, Qin T, Xu Z, Zhang H, Fang L, Pan L, Hu N, Qu S, Huang G, Gale RP, Xiao Z

British journal of haematology · DOI 10.1111/bjh.15830 · PMID 30836422

2019 May

Hypoxia/pseudohypoxia-mediated activation of hypoxia-inducible factor-1α in cancer

Hayashi Y, Yokota A, Harada H, Huang G

Cancer science · DOI 10.1111/cas.13990 · PMID 30844107

2019 Apr

RUNX represses Pmp22 to drive neurofibromagenesis

Hall A, Choi K, Liu W, Rose J, Zhao C, Yu Y, Na Y, Cai Y, Coover RA, Lin Y, Dombi E, Kim M, Levanon D, Groner Y, Boscolo E, Pan D, Liu PP, Lu QR, Ratner N, Huang G, Wu J

Science advances · DOI 10.1126/sciadv.aau8389 · PMID 31032403

2019 Mar

Histone H3 trimethylation at lysine 36 guides m(6)A RNA modification co-transcriptionally

Huang H, Weng H, Zhou K, Wu T, Zhao BS, Sun M, Chen Z, Deng X, Xiao G, Auer F, Klemm L, Wu H, Zuo Z, Qin X, Dong Y, Zhou Y, Qin H, Tao S, Du J, Liu J, Lu Z, Yin H, Mesquita A, Yuan CL, Hu YC, Sun W, Su R, Dong L, Shen C, Li C, Qing Y, Jiang X, Wu X, Sun M, Guan JL, Qu L, Wei M, Müschen M, Huang G, He C, Yang J, Chen J

Nature · DOI 10.1038/s41586-019-1016-7 · PMID 30867593

2019 Mar

The high NRF2 expression confers chemotherapy resistance partly through up-regulated DUSP1 in myelodysplastic syndromes

Lin P, Ren Y, Yan X, Luo Y, Zhang H, Kesarwani M, Bu J, Zhan D, Zhou Y, Tang Y, Zhu S, Xu W, Zhou X, Mei C, Ma L, Ye L, Hu C, Azam M, Ding W, Jin J, Huang G, Tong H

Haematologica · DOI 10.3324/haematol.2018.197749 · PMID 30262569

2019 Feb

[Consistency Analysis of Gene Mutation Sites of Bone Marrow Tumor DNA and Circulating Tumor DNA in Patients with Myelodysplastic Syndrome]

Zhao P, Zhu QZ, Fan T, Liu WY, Xiao HY, Qin JY, Huang G, Hu XM

Zhongguo shi yan xue ye xue za zhi · DOI 10.7534/j.issn.1009-2137.2019.01.024 · PMID 30738462

2018 Dec 10

A Transcription Factor Addiction in Leukemia Imposed by the MLL Promoter Sequence

Lu B, Klingbeil O, Tarumoto Y, Somerville TDD, Huang YH, Wei Y, Wai DC, Low JKK, Milazzo JP, Wu XS, Cao Z, Yan X, Demerdash OE, Huang G, Mackay JP, Kinney JB, Shi J, Vakoc CR

Cancer cell · DOI 10.1016/j.ccell.2018.10.015 · PMID 30503706

2018 Dec

The usefulness of mutational data on prognosis of myelodysplastic syndromes: alone or incorporated into the IPSS-R?

Li B, Liu J, Xu Z, Qin T, Shi Z, Song Z, Huang H, Fang L, Zhang H, Pan L, Hu N, Qu S, Zhang Y, Huang G, Xiao Z

British journal of haematology · DOI 10.1111/bjh.15036 · PMID 29193004

2018 Nov

Pathobiological Pseudohypoxia as a Putative Mechanism Underlying Myelodysplastic Syndromes

Hayashi Y, Zhang Y, Yokota A, Yan X, Liu J, Choi K, Li B, Sashida G, Peng Y, Xu Z, Huang R, Zhang L, Freudiger GM, Wang J, Dong Y, Zhou Y, Wang J, Wu L, Bu J, Chen A, Zhao X, Sun X, Chetal K, Olsson A, Watanabe M, Romick-Rosendale LE, Harada H, Shih LY, Tse W, Bridges JP, Caligiuri MA, Huang T, Zheng Y, Witte DP, Wang QF, Qu CK, Salomonis N, Grimes HL, Nimer SD, Xiao Z, Huang G

Cancer discovery · DOI 10.1158/2159-8290.CD-17-1203 · PMID 30139811

2018 Oct 23

Defective transcription elongation in a subset of cancers confers immunotherapy resistance

Modur V, Singh N, Mohanty V, Chung E, Muhammad B, Choi K, Chen X, Chetal K, Ratner N, Salomonis N, Weirauch MT, Waltz S, Huang G, Privette-Vinnedge L, Park JS, Janssen EM, Komurov K

Nature communications · DOI 10.1038/s41467-018-06810-0 · PMID 30353012

2018 Oct

A novel fusion of PDGFRB to TSC1, an intrinsic suppressor of mTOR-signaling pathway, in a chronic eosinophilic leukemia patient with t(5;9)(q32;q34)

Zhang Y, Qu S, Wang Q, Li J, Xu Z, Qin T, Huang G, Xiao Z

Leukemia & lymphoma · DOI 10.1080/10428194.2018.1427855 · PMID 29384404

2018 Oct

Loss of YTHDF2-mediated m(6)A-dependent mRNA clearance facilitates hematopoietic stem cell regeneration

Wang H, Zuo H, Liu J, Wen F, Gao Y, Zhu X, Liu B, Xiao F, Wang W, Huang G, Shen B, Ju Z

Cell research · DOI 10.1038/s41422-018-0082-y · PMID 30150673

2018 Jul

Setd2 regulates quiescence and differentiation of adult hematopoietic stem cells by restricting RNA polymerase II elongation

Zhou Y, Yan X, Feng X, Bu J, Dong Y, Lin P, Hayashi Y, Huang R, Olsson A, Andreassen PR, Grimes HL, Wang QF, Cheng T, Xiao Z, Jin J, Huang G

Haematologica · DOI 10.3324/haematol.2018.187708 · PMID 29650642

2018 Apr

SETD2-mediated crosstalk between H3K36me3 and H3K79me2 in MLL-rearranged leukemia

Bu J, Chen A, Yan X, He F, Dong Y, Zhou Y, He J, Zhan D, Lin P, Hayashi Y, Sun Y, Zhang Y, Xiao Z, Grimes HL, Wang QF, Huang G

Leukemia · DOI 10.1038/leu.2017.339 · PMID 29249820

2018 Feb 12

SF3B1 deficiency impairs human erythropoiesis via activation of p53 pathway: implications for understanding of ineffective erythropoiesis in MDS

Huang Y, Hale J, Wang Y, Li W, Zhang S, Zhang J, Zhao H, Guo X, Liu J, Yan H, Yazdanbakhsh K, Huang G, Hillyer CD, Mohandas N, Chen L, Sun L, An X

Journal of hematology & oncology · DOI 10.1186/s13045-018-0558-8 · PMID 29433555

2018 Feb

Clinical features and biological implications of different U2AF1 mutation types in myelodysplastic syndromes

Li B, Liu J, Jia Y, Wang J, Xu Z, Qin T, Shi Z, Song Z, Peng S, Huang H, Fang L, Zhang H, Pan L, Hu N, Qu S, Zhang Y, Wu J, Liu N, Ru K, Huang G, Xiao Z

Genes, chromosomes & cancer · DOI 10.1002/gcc.22510 · PMID 29057546

2018 Feb

Integrated genomic analysis identifies deregulated JAK/STAT-MYC-biosynthesis axis in aggressive NK-cell leukemia

Huang L, Liu D, Wang N, Ling S, Tang Y, Wu J, Hao L, Luo H, Hu X, Sheng L, Zhu L, Wang D, Luo Y, Shang Z, Xiao M, Mao X, Zhou K, Cao L, Dong L, Zheng X, Sui P, He J, Mo S, Yan J, Ao Q, Qiu L, Zhou H, Liu Q, Zhang H, Li J, Jin J, Fu L, Zhao W, Chen J, Du X, Qing G, Liu H, Liu X, Huang G, Ma D, Zhou J, Wang QF

Cell research · DOI 10.1038/cr.2017.146 · PMID 29148541

2018 Feb

Whole exome sequencing identifies novel mutations of epigenetic regulators in chemorefractory pediatric acute myeloid leukemia

Zhan D, Zhang Y, Xiao P, Zheng X, Ruan M, Zhang J, Chen A, Zou Y, Chen Y, Huang G, Hu S, Wang QF, Zhu X

Leukemia research · DOI 10.1016/j.leukres.2017.12.001 · PMID 29253671

2018 Jan 15

Thalidomide plus prednisone with or without danazol therapy in myelofibrosis: a retrospective analysis of incidence and durability of anemia response

Luo X, Xu Z, Li B, Qin T, Zhang P, Zhang H, Fang L, Pan L, Hu N, Qu S, Zhang Y, Huang G, Peter Gale R, Xiao Z

Blood cancer journal · DOI 10.1038/s41408-017-0029-4 · PMID 29335406

2018 Jan

Expansion of EPOR-negative macrophages besides erythroblasts by elevated EPOR signaling in erythrocytosis mouse models

Wang J, Hayashi Y, Yokota A, Xu Z, Zhang Y, Huang R, Yan X, Liu H, Ma L, Azam M, Bridges JP, Cancelas JA, Kalfa TA, An X, Xiao Z, Huang G

Haematologica · DOI 10.3324/haematol.2017.172775 · PMID 29051279

2017 Dec 21

Aggressive NK-cell leukemia: clinical subtypes, molecular features, and treatment outcomes

Tang YT, Wang D, Luo H, Xiao M, Zhou HS, Liu D, Ling SP, Wang N, Hu XL, Luo Y, Mao X, Ao QL, Huang J, Zhang W, Sheng LS, Zhu LJ, Shang Z, Gao LL, Zhang PL, Zhou M, Zhou KG, Qiu LG, Liu QF, Zhang HY, Li JY, Jin J, Fu L, Zhao WL, Chen JP, Du X, Huang G, Wang QF, Zhou JF, Huang L

Blood cancer journal · DOI 10.1038/s41408-017-0021-z · PMID 29263371

2017 Nov

HIF1A is a critical downstream mediator for hemophagocytic lymphohistiocytosis

Huang R, Hayashi Y, Yan X, Bu J, Wang J, Zhang Y, Zhou Y, Tang Y, Wu L, Xu Z, Liu X, Wang Q, Zhou J, Xiao Z, Bridges JP, Marsh RA, Zhang K, Jordan MB, Li Y, Huang G

Haematologica · DOI 10.3324/haematol.2017.174979 · PMID 28860338

2017 Aug

Myeloid neoplasms with germ line RUNX1 mutation

Hayashi Y, Harada Y, Huang G, Harada H

International journal of hematology · DOI 10.1007/s12185-017-2258-5 · PMID 28534116

2017 May 2

Non-driver mutations in myeloproliferative neoplasm-associated myelofibrosis

Li B, Gale RP, Xu Z, Qin T, Song Z, Zhang P, Bai J, Zhang L, Zhang Y, Liu J, Huang G, Xiao Z

Journal of hematology & oncology · DOI 10.1186/s13045-017-0472-5 · PMID 28464892

2017 Mar

MLF1IP promotes normal erythroid proliferation and is involved in the pathogenesis of polycythemia vera

Feng G, Zhang T, Liu J, Ma X, Li B, Yang L, Zhang Y, Xu Z, Qin T, Zhou J, Huang G, Shi L, Xiao Z

FEBS letters · DOI 10.1002/1873-3468.12587 · PMID 28173615

2017 Jan 3

Multiplex ligation-dependent probe amplification assay identifies additional copy number changes compared with R-band karyotype and provide more accuracy prognostic information in myelodysplastic syndromes

Wang J, Ai X, Qin T, Xu Z, Zhang Y, Liu J, Li B, Fang L, Zhang H, Pan L, Hu N, Qu S, Cai W, Ru K, Jia Y, Huang G, Xiao Z

Oncotarget · DOI 10.18632/oncotarget.13688 · PMID 27906673

2017

Covalent Modifications of RUNX Proteins: Structure Affects Function

Blumenthal E, Greenblatt S, Huang G, Ando K, Xu Y, Nimer SD

Advances in experimental medicine and biology · DOI 10.1007/978-981-10-3233-2_3 · PMID 28299649

2017

Unraveling Macrophage Heterogeneity in Erythroblastic Islands

Seu KG, Papoin J, Fessler R, Hom J, Huang G, Mohandas N, Blanc L, Kalfa TA

Frontiers in immunology · DOI 10.3389/fimmu.2017.01140 · PMID 28979259

2016 Dec 9

Bone marrow fibrosis grade is an independent risk factor for overall survival in patients with primary myelofibrosis

Li B, Zhang P, Feng G, Xu Z, Qin T, Zhang Y, Sha Z, Dong D, Zhang H, Fang L, Pan L, Hu N, Qu S, Cai W, Huang G, Xiao Z

Blood cancer journal · DOI 10.1038/bcj.2016.116 · PMID 27935577

2016 Nov 10

Leukaemogenic effects of Ptpn11 activating mutations in the stem cell microenvironment

Dong L, Yu WM, Zheng H, Loh ML, Bunting ST, Pauly M, Huang G, Zhou M, Broxmeyer HE, Scadden DT, Qu CK

Nature · DOI 10.1038/nature20131 · PMID 27783593

2016 Oct 18

Colony-forming unit cell (CFU-C) assays at diagnosis: CFU-G/M cluster predicts overall survival in myelodysplastic syndrome patients independently of IPSS-R

Li B, Liu J, Qu S, Gale RP, Song Z, Xing R, Liu J, Ren Y, Xu Z, Qin T, Zhang Y, Fang L, Zhang H, Pan L, Hu N, Cai W, Zhang P, Huang G, Xiao Z

Oncotarget · DOI 10.18632/oncotarget.12105 · PMID 27655727

2016 Aug 9

Supraphysiologic levels of the AML1-ETO isoform AE9a are essential for transformation

Link KA, Lin S, Shrestha M, Bowman M, Wunderlich M, Bloomfield CD, Huang G, Mulloy JC

Proceedings of the National Academy of Sciences of the United States of America · DOI 10.1073/pnas.1524225113 · PMID 27457952

2016 Jul

The different prognostic impact of type-1 or type-1 like and type-2 or type-2 like CALR mutations in patients with primary myelofibrosis

Li B, Xu Z, Li Y, Peter Gale R, Song Z, Ai X, Qin T, Zhang Y, Zhang P, Huang G, Xiao Z

American journal of hematology · DOI 10.1002/ajh.24378 · PMID 27059877

2016 May 12

Differential role of Id1 in MLL-AF9-driven leukemia based on cell of origin

Man N, Sun XJ, Tan Y, García-Cao M, Liu F, Cheng G, Hatlen M, Xu H, Shah R, Chastain N, Liu N, Huang G, Zhou Y, Sheng M, Song J, Yang FC, Benezra R, Nimer SD, Wang L

Blood · DOI 10.1182/blood-2015-11-677708 · PMID 26944543

2016 Mar 17

Runx1 contributes to neurofibromatosis type 1 neurofibroma formation

Li H, Zhao X, Yan X, Jessen WJ, Kim MO, Dombi E, Liu PP, Huang G, Wu J

Oncogene · DOI 10.1038/onc.2015.207 · PMID 26073082

2016 Mar 17

SON and Its Alternatively Spliced Isoforms Control MLL Complex-Mediated H3K4me3 and Transcription of Leukemia-Associated Genes

Kim JH, Baddoo MC, Park EY, Stone JK, Park H, Butler TW, Huang G, Yan X, Pauli-Behn F, Myers RM, Tan M, Flemington EK, Lim ST, Ahn EY

Molecular cell · DOI 10.1016/j.molcel.2016.02.024 · PMID 26990989

2016 Mar 1

Insertional Mutagenesis Identifies a STAT3/Arid1b/β-catenin Pathway Driving Neurofibroma Initiation

Wu J, Keng VW, Patmore DM, Kendall JJ, Patel AV, Jousma E, Jessen WJ, Choi K, Tschida BR, Silverstein KA, Fan D, Schwartz EB, Fuchs JR, Zou Y, Kim MO, Dombi E, Levy DE, Huang G, Cancelas JA, Stemmer-Rachamimov AO, Spinner RJ, Largaespada DA, Ratner N

Cell reports · DOI 10.1016/j.celrep.2016.01.074 · PMID 26904939

2016 Jan 8

RUNX1 haploinsufficiency results in granulocyte colony-stimulating factor hypersensitivity

Chin DW, Sakurai M, Nah GS, Du L, Jacob B, Yokomizo T, Matsumura T, Suda T, Huang G, Fu XY, Ito Y, Nakajima H, Osato M

Blood cancer journal · DOI 10.1038/bcj.2015.105 · PMID 26745853

2016

TET2 mutations were predictive of inferior prognosis in the presence of ASXL1 mutations in patients with chronic myelomonocytic leukemia

Cui Y, Tong H, Du X, Li B, Gale RP, Qin T, Liu J, Xu Z, Zhang Y, Huang G, Jin J, Fang L, Zhang H, Pan L, Hu N, Qu S, Xiao Z

Stem cell investigation · DOI 10.21037/sci.2016.09.04 · PMID 27777939

2015 Aug 21

AF1q is a novel TCF7 co-factor which activates CD44 and promotes breast cancer metastasis

Park J, Schlederer M, Schreiber M, Ice R, Merkel O, Bilban M, Hofbauer S, Kim S, Addison J, Zou J, Ji C, Bunting ST, Wang Z, Shoham M, Huang G, Bago-Horvath Z, Gibson LF, Rojanasakul Y, Remick S, Ivanov A, Pugacheva E, Bunting KD, Moriggl R, Kenner L, Tse W

Oncotarget · DOI 10.18632/oncotarget.4136 · PMID 26079538

2015 Jul 30

Regulation of AKT signaling by Id1 controls t(8;21) leukemia initiation and progression

Wang L, Man N, Sun XJ, Tan Y, García-Cao M, Liu F, Hatlen M, Xu H, Huang G, Mattlin M, Mehta A, Rampersaud E, Benezra R, Nimer SD

Blood · DOI 10.1182/blood-2015-03-635532 · PMID 26084673

2015 Jul

Posttranslational modifications of RUNX1 as potential anticancer targets

Goyama S, Huang G, Kurokawa M, Mulloy JC

Oncogene · DOI 10.1038/onc.2014.305 · PMID 25263451

2015 May

MLL partial tandem duplication leukemia cells are sensitive to small molecule DOT1L inhibition

Kühn MW, Hadler MJ, Daigle SR, Koche RP, Krivtsov AV, Olhava EJ, Caligiuri MA, Huang G, Bradner JE, Pollock RM, Armstrong SA

Haematologica · DOI 10.3324/haematol.2014.115337 · PMID 25596271

2015 Apr 16

MEIS1 regulates an HLF-oxidative stress axis in MLL-fusion gene leukemia

Roychoudhury J, Clark JP, Gracia-Maldonado G, Unnisa Z, Wunderlich M, Link KA, Dasgupta N, Aronow B, Huang G, Mulloy JC, Kumar AR

Blood · DOI 10.1182/blood-2014-09-599258 · PMID 25740828

2015

A systematic classification of megakaryocytic dysplasia and its impact on prognosis for patients with myelodysplastic syndromes

Feng G, Gale RP, Cui W, Cai W, Huang G, Xu Z, Qin T, Zhang Y, Li B, Fang L, Zhang H, Pan L, Hu N, Qu S, Wang J, Cui Y, Xiao Z

Experimental hematology & oncology · DOI 10.1186/s40164-016-0041-6 · PMID 27127725

2015

Impact of TET2, SRSF2, ASXL1 and SETBP1 mutations on survival of patients with chronic myelomonocytic leukemia

Cui Y, Tong H, Du X, Li B, Gale RP, Qin T, Liu J, Xu Z, Zhang Y, Huang G, Jin J, Fang L, Zhang H, Pan L, Hu N, Qu S, Xiao Z

Experimental hematology & oncology · DOI 10.1186/s40164-015-0009-y · PMID 26019984

2015

Runx1: a new driver in neurofibromagenesis

Wu J, Huang G, Ratner N

Oncoscience · DOI 10.18632/oncoscience.266 · PMID 26697518

2014 Nov

Cytogenetic studies and their prognostic contribution in 565 Chinese patients with primary myelofibrosis

Li B, Xu J, Li C, Gale RP, Xu Z, Qin T, Zhang Y, Huang G, Fang L, Zhang H, Pan L, Hu N, Qu S, Xiao Z

American journal of hematology · DOI 10.1002/ajh.23824 · PMID 25132428

2014 Oct 9

The Runx-PU.1 pathway preserves normal and AML/ETO9a leukemic stem cells

Staber PB, Zhang P, Ye M, Welner RS, Levantini E, Di Ruscio A, Ebralidze AK, Bach C, Zhang H, Zhang J, Vanura K, Delwel R, Yang H, Huang G, Tenen DG

Blood · DOI 10.1182/blood-2014-01-550855 · PMID 25185713

2014 Jul

PU.1 is essential for MLL leukemia partially via crosstalk with the MEIS/HOX pathway

Zhou J, Wu J, Li B, Liu D, Yu J, Yan X, Zheng S, Wang J, Zhang L, Zhang L, He F, Li Q, Chen A, Zhang Y, Zhao X, Guan Y, Zhao X, Yan J, Ni J, Nobrega MA, Löwenberg B, Delwel R, Valk PJ, Kumar A, Xie L, Tenen DG, Huang G, Wang QF

Leukemia · DOI 10.1038/leu.2013.384 · PMID 24445817

2014 Jun 23

Ezh2 loss promotes development of myelodysplastic syndrome but attenuates its predisposition to leukaemic transformation

Sashida G, Harada H, Matsui H, Oshima M, Yui M, Harada Y, Tanaka S, Mochizuki-Kashio M, Wang C, Saraya A, Muto T, Hayashi Y, Suzuki K, Nakajima H, Inaba T, Koseki H, Huang G, Kitamura T, Iwama A

Nature communications · DOI 10.1038/ncomms5177 · PMID 24953053

2014 May

Serum iron metabolism and erythropoiesis in patients with myelodysplastic syndrome not receiving RBC transfusions

Cui R, Gale RP, Zhu G, Xu Z, Qin T, Zhang Y, Huang G, Li B, Fang L, Zhang H, Pan L, Hu N, Qu S, Xiao Z

Leukemia research · DOI 10.1016/j.leukres.2014.01.016 · PMID 24598841

2014 Mar 13

Downregulation of RUNX1/CBFβ by MLL fusion proteins enhances hematopoietic stem cell self-renewal

Zhao X, Chen A, Yan X, Zhang Y, He F, Hayashi Y, Dong Y, Rao Y, Li B, Conway RM, Maiques-Diaz A, Elf SE, Huang N, Zuber J, Xiao Z, Tse W, Tenen DG, Wang Q, Chen W, Mulloy JC, Nimer SD, Huang G

Blood · DOI 10.1182/blood-2013-03-489575 · PMID 24449215

2014 Mar

Identification of functional cooperative mutations of SETD2 in human acute leukemia

Zhu X, He F, Zeng H, Ling S, Chen A, Wang Y, Yan X, Wei W, Pang Y, Cheng H, Hua C, Zhang Y, Yang X, Lu X, Cao L, Hao L, Dong L, Zou W, Wu J, Li X, Zheng S, Yan J, Zhou J, Zhang L, Mi S, Wang X, Zhang L, Zou Y, Chen Y, Geng Z, Wang J, Zhou J, Liu X, Wang J, Yuan W, Huang G, Cheng T, Wang QF

Nature genetics · DOI 10.1038/ng.2894 · PMID 24509477

2013 Oct

A SALL4/MLL/HOXA9 pathway in murine and human myeloid leukemogenesis

Li A, Yang Y, Gao C, Lu J, Jeong HW, Liu BH, Tang P, Yao X, Neuberg D, Huang G, Tenen DG, Chai L

The Journal of clinical investigation · DOI 10.1172/JCI62891 · PMID 24051379

2013 Sep

RUNX1 meets MLL: epigenetic regulation of hematopoiesis by two leukemia genes

Koh CP, Wang CQ, Ng CE, Ito Y, Araki M, Tergaonkar V, Huang G, Osato M

Leukemia · DOI 10.1038/leu.2013.200 · PMID 23817177

2013 Sep

Transcription factor RUNX1 promotes survival of acute myeloid leukemia cells

Goyama S, Schibler J, Cunningham L, Zhang Y, Rao Y, Nishimoto N, Nakagawa M, Olsson A, Wunderlich M, Link KA, Mizukawa B, Grimes HL, Kurokawa M, Liu PP, Huang G, Mulloy JC

The Journal of clinical investigation · DOI 10.1172/JCI68557 · PMID 23979164

2013 May 30

PU.1 level-directed chromatin structure remodeling at the Irf8 gene drives dendritic cell commitment

Schönheit J, Kuhl C, Gebhardt ML, Klett FF, Riemke P, Scheller M, Huang G, Naumann R, Leutz A, Stocking C, Priller J, Andrade-Navarro MA, Rosenbauer F

Cell reports · DOI 10.1016/j.celrep.2013.04.007 · PMID 23623495

2013 Apr

Creation of a six-fingered artificial transcription factor that represses the hepatitis B virus HBx gene integrated into a human hepatocellular carcinoma cell line

Zhao X, Zhao Z, Guo J, Huang P, Zhu X, Zhou X, Yang Z, Zhao L, Xu L, Xu J, Fu L, Zhang J, Zhang X, Dong Y, Huang G, Wang Q, Li B, Song X, Yang X, Liu S, Yi S, Yu T, Yu C, Hou L, Li J, Chen W

Journal of biomolecular screening · DOI 10.1177/1087057112463066 · PMID 23042077

2013 Mar 7

Sustained PU.1 levels balance cell-cycle regulators to prevent exhaustion of adult hematopoietic stem cells

Staber PB, Zhang P, Ye M, Welner RS, Nombela-Arrieta C, Bach C, Kerenyi M, Bartholdy BA, Zhang H, Alberich-Jordà M, Lee S, Yang H, Ng F, Zhang J, Leddin M, Silberstein LE, Hoefler G, Orkin SH, Göttgens B, Rosenbauer F, Huang G, Tenen DG

Molecular cell · DOI 10.1016/j.molcel.2013.01.007 · PMID 23395001

2013

Cyclic AMP responsive element binding proteins are involved in 'emergency' granulopoiesis through the upregulation of CCAAT/enhancer binding protein β

Hirai H, Kamio N, Huang G, Matsusue A, Ogino S, Kimura N, Satake S, Ashihara E, Imanishi J, Tenen DG, Maekawa T

PloS one · DOI 10.1371/journal.pone.0054862 · PMID 23382991

2012 Oct

Disordered epigenetic regulation in MLL-related leukemia

Zhang Y, Chen A, Yan XM, Huang G

International journal of hematology · DOI 10.1007/s12185-012-1180-0 · PMID 23054645

2012 Aug 2

Mll partial tandem duplication and Flt3 internal tandem duplication in a double knock-in mouse recapitulates features of counterpart human acute myeloid leukemias

Zorko NA, Bernot KM, Whitman SP, Siebenaler RF, Ahmed EH, Marcucci GG, Yanes DA, McConnell KK, Mao C, Kalu C, Zhang X, Jarjoura D, Dorrance AM, Heerema NA, Lee BH, Huang G, Marcucci G, Caligiuri MA

Blood · DOI 10.1182/blood-2012-03-415067 · PMID 22674806

2012 Aug 2

Stress hematopoiesis reveals abnormal control of self-renewal, lineage bias, and myeloid differentiation in Mll partial tandem duplication (Mll-PTD) hematopoietic stem/progenitor cells

Zhang Y, Yan X, Sashida G, Zhao X, Rao Y, Goyama S, Whitman SP, Zorko N, Bernot K, Conway RM, Witte D, Wang QF, Tenen DG, Xiao Z, Marcucci G, Mulloy JC, Grimes HL, Caligiuri MA, Huang G

Blood · DOI 10.1182/blood-2012-02-412379 · PMID 22740449

2011 Dec 15

The ability of MLL to bind RUNX1 and methylate H3K4 at PU.1 regulatory regions is impaired by MDS/AML-associated RUNX1/AML1 mutations

Huang G, Zhao X, Wang L, Elf S, Xu H, Zhao X, Sashida G, Zhang Y, Liu Y, Lee J, Menendez S, Yang Y, Yan X, Zhang P, Tenen DG, Osato M, Hsieh JJ, Nimer SD

Blood · DOI 10.1182/blood-2010-11-317909 · PMID 22012064

2011 Aug 26

RUNX1 regulates the CD34 gene in haematopoietic stem cells by mediating interactions with a distal regulatory element

Levantini E, Lee S, Radomska HS, Hetherington CJ, Alberich-Jorda M, Amabile G, Zhang P, Gonzalez DA, Zhang J, Basseres DS, Wilson NK, Koschmieder S, Huang G, Zhang DE, Ebralidze AK, Bonifer C, Okuno Y, Gottgens B, Tenen DG

The EMBO journal · DOI 10.1038/emboj.2011.285 · PMID 21873977

2011 Aug 5

The leukemogenicity of AML1-ETO is dependent on site-specific lysine acetylation

Wang L, Gural A, Sun XJ, Zhao X, Perna F, Huang G, Hatlen MA, Vu L, Liu F, Xu H, Asai T, Xu H, Deblasio T, Menendez S, Voza F, Jiang Y, Cole PA, Zhang J, Melnick A, Roeder RG, Nimer SD

Science (New York, N.Y.) · DOI 10.1126/science.1201662 · PMID 21764752

2011 Jul 15

The mef/elf4 transcription factor fine tunes the DNA damage response

Sashida G, Bae N, Di Giandomenico S, Asai T, Gurvich N, Bazzoli E, Liu Y, Huang G, Zhao X, Menendez S, Nimer SD

Cancer research · DOI 10.1158/0008-5472.CAN-11-0455 · PMID 21616937

2011 Jun

MIR29B regulates expression of MLLT11 (AF1Q), an MLL fusion partner, and low MIR29B expression associates with adverse cytogenetics and poor overall survival in AML

Xiong Y, Li Z, Ji M, Tan AC, Bemis J, Tse JV, Huang G, Park J, Ji C, Chen J, Bemis LT, Bunting KD, Tse W

British journal of haematology · DOI 10.1111/j.1365-2141.2011.08662.x · PMID 21496004

2010 Jul

CARM1 is required for proper control of proliferation and differentiation of pulmonary epithelial cells

O'Brien KB, Alberich-Jordà M, Yadav N, Kocher O, Diruscio A, Ebralidze A, Levantini E, Sng NJ, Bhasin M, Caron T, Kim D, Steidl U, Huang G, Halmos B, Rodig SJ, Bedford MT, Tenen DG, Kobayashi S

Development (Cambridge, England) · DOI 10.1242/dev.037150 · PMID 20530543

2010 May 18

Accelerated leukemogenesis by truncated CBF beta-SMMHC defective in high-affinity binding with RUNX1

Kamikubo Y, Zhao L, Wunderlich M, Corpora T, Hyde RK, Paul TA, Kundu M, Garrett L, Compton S, Huang G, Wolff L, Ito Y, Bushweller J, Mulloy JC, Liu PP

Cancer cell · DOI 10.1016/j.ccr.2010.03.022 · PMID 20478528

2009 Oct 1

The p53 tumor suppressor protein is a critical regulator of hematopoietic stem cell behavior

Liu Y, Elf SE, Asai T, Miyata Y, Liu Y, Sashida G, Huang G, Di Giandomenico S, Koff A, Nimer SD

Cell cycle (Georgetown, Tex.) · DOI 10.4161/cc.8.19.9627 · PMID 19755852

2009 Jan 9

p53 regulates hematopoietic stem cell quiescence

Liu Y, Elf SE, Miyata Y, Sashida G, Liu Y, Huang G, Di Giandomenico S, Lee JM, Deblasio A, Menendez S, Antipin J, Reva B, Koff A, Nimer SD

Cell stem cell · DOI 10.1016/j.stem.2008.11.006 · PMID 19128791

2008 Sep

Genetic evidence of PEBP2beta-independent activation of Runx1 in the murine embryo

Yokomizo T, Yanagida M, Huang G, Osato M, Honda C, Ema M, Takahashi S, Yamamoto M, Ito Y

International journal of hematology · DOI 10.1007/s12185-008-0121-4 · PMID 18594778

2008 Aug 1

PU.1 expression is modulated by the balance of functional sense and antisense RNAs regulated by a shared cis-regulatory element

Ebralidze AK, Guibal FC, Steidl U, Zhang P, Lee S, Bartholdy B, Jorda MA, Petkova V, Rosenbauer F, Huang G, Dayaram T, Klupp J, O'Brien KB, Will B, Hoogenkamp M, Borden KL, Bonifer C, Tenen DG

Genes & development · DOI 10.1101/gad.1654808 · PMID 18676813

2008 Mar 1

Methylation of RUNX1 by PRMT1 abrogates SIN3A binding and potentiates its transcriptional activity

Zhao X, Jankovic V, Gural A, Huang G, Pardanani A, Menendez S, Zhang J, Dunne R, Xiao A, Erdjument-Bromage H, Allis CD, Tempst P, Nimer SD

Genes & development · DOI 10.1101/gad.1632608 · PMID 18316480

2008 Jan

PU.1 is a major downstream target of AML1 (RUNX1) in adult mouse hematopoiesis

Huang G, Zhang P, Hirai H, Elf S, Yan X, Chen Z, Koschmieder S, Okuno Y, Dayaram T, Growney JD, Shivdasani RA, Gilliland DG, Speck NA, Nimer SD, Tenen DG

Nature genetics · DOI 10.1038/ng.2007.7 · PMID 17994017

2007 Nov

The Pu.1 locus is differentially regulated at the level of chromatin structure and noncoding transcription by alternate mechanisms at distinct developmental stages of hematopoiesis

Hoogenkamp M, Krysinska H, Ingram R, Huang G, Barlow R, Clarke D, Ebralidze A, Zhang P, Tagoh H, Cockerill PN, Tenen DG, Bonifer C

Molecular and cellular biology · DOI 10.1128/MCB.00905-07 · PMID 17785440

2005 Apr

Potential autoregulation of transcription factor PU.1 by an upstream regulatory element

Okuno Y, Huang G, Rosenbauer F, Evans EK, Radomska HS, Iwasaki H, Akashi K, Moreau-Gachelin F, Li Y, Zhang P, Göttgens B, Tenen DG

Molecular and cellular biology · DOI 10.1128/MCB.25.7.2832-2845.2005 · PMID 15767686

2004 Apr 15

Molecular basis for a dominant inactivation of RUNX1/AML1 by the leukemogenic inversion 16 chimera

Huang G, Shigesada K, Wee HJ, Liu PP, Osato M, Ito Y

Blood · DOI 10.1182/blood-2003-07-2188 · PMID 15070703

2002 Oct

Serine phosphorylation of RUNX2 with novel potential functions as negative regulatory mechanisms

Wee HJ, Huang G, Shigesada K, Ito Y

EMBO reports · DOI 10.1093/embo-reports/kvf193 · PMID 12231506

2001 Feb 15

Dimerization with PEBP2beta protects RUNX1/AML1 from ubiquitin-proteasome-mediated degradation

Huang G, Shigesada K, Ito K, Wee HJ, Yokomizo T, Ito Y

The EMBO journal · DOI 10.1093/emboj/20.4.723 · PMID 11179217

2000 Sep 12

A RUNX2/PEBP2alpha A/CBFA1 mutation displaying impaired transactivation and Smad interaction in cleidocranial dysplasia

Zhang YW, Yasui N, Ito K, Huang G, Fujii M, Hanai J, Nogami H, Ochi T, Miyazono K, Ito Y

Proceedings of the National Academy of Sciences of the United States of America · DOI 10.1073/pnas.180309597 · PMID 10962029

1999 Jul 15

Block of granulocytic differentiation of 32Dcl3 cells by AML1/ETO(MTG8) but not by highly expressed Bcl-2

Kohzaki H, Ito K, Huang G, Wee HJ, Murakami Y, Ito Y

Oncogene · DOI 10.1038/sj.onc.1202735 · PMID 10435586

1998 Feb 17

Negative regulation of granulocytic differentiation in the myeloid precursor cell line 32Dcl3 by ear-2, a mammalian homolog of Drosophila seven-up, and a chimeric leukemogenic gene, AML1/ETO

Ahn MY, Huang G, Bae SC, Wee HJ, Kim WY, Ito Y

Proceedings of the National Academy of Sciences of the United States of America · DOI 10.1073/pnas.95.4.1812 · PMID 9465099

1997 Jul

A novel transcript encoding an N-terminally truncated AML1/PEBP2 alphaB protein interferes with transactivation and blocks granulocytic differentiation of 32Dcl3 myeloid cells

Zhang YW, Bae SC, Huang G, Fu YX, Lu J, Ahn MY, Kanno Y, Kanno T, Ito Y

Molecular and cellular biology · DOI 10.1128/MCB.17.7.4133 · PMID 9199349

A Critical Role of RUNX1 in Governing Megakaryocyte-Primed Hematopoietic Stem Cell Differentiation

Blood advances

Forthcoming

Trisomy 8 alters chromatin conformations and activates Y chromosome genes in stem cell to drive a pre-leukemic state

Bai J.

Oncogene

Forthcoming

Valosin-Containing Protein Contributes to Plexiform Neurofibroma Formation and Represents a Novel Therapeutic Target

Gopalan L, Huang G.

Preprints.org