Publications | Huang Lab

2026 May

Trisomy 8 alters chromatin conformations and activates Y chromosome genes in stem cells to drive a pre-leukemic state

Bai J, Araki K, Kurotaki D, Eerdunduleng, Sorin S, Hiramatsu K, Uno N, Hamashima A, Iimori M, Kikuchi K, Terashima M, Kubota S, Kohrogi K, Huang G, Ogawa M, Oshimura M, Kazuki Y, Sashida G

Oncogene · DOI 10.1038/s41388-026-03763-3 · PMID 41933136

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2026 Apr 8

Insights and modulation of RNA polymerase-dependent R-loop and dsRNA in Fanconi anemia hematopoietic stem cells

Hashimoto M, Feng X, Bai J, Zeng H, Li T, Li J, Umemoto T, Andreassen PR, Huang G

JCI insight · DOI 10.1172/jci.insight.192126 · PMID 41746738

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2026 Mar

Driver mutation-defined molecular landscapes of essential thrombocythemia

Lorenzen AL, Huang G

Blood science (Baltimore, Md.) · DOI 10.1097/BS9.0000000000000273 · PMID 41552765

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2026 March

Valosin-Containing Protein Contributes to Plexiform Neurofibroma Formation and Represents a Novel Therapeutic Target

Gopalan L, Na Y, Hu L, Hall A, Kim M, Dombi E, Szabo S, Ratner N, Huang G, Wu J.

Cells · DOI 10.3390/cells15090848

DOI

2026 Feb 2

Luspatercept ameliorates disease phenotype and complications in the Townes mouse model of sickle cell disease

Sezaki M, Li T, Pan M, Wang Z, Bai J, Horowitz JG, Xu JZ, Huang G

The Journal of clinical investigation · DOI 10.1172/JCI197706 · PMID 41623180

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2025 Nov 7

The RNA N(6)-methyladenosine methylome coordinates long non-coding RNAs to mediate cancer drug resistance by activating PI3K signaling

Tan Y, Zhou C, Bian S, Bian H, Ren Y, Walter W, Pang J, Cheng T, Wang H, Yang Y, Guo W, Zhang L, Al-Kali A, Litzow MR, Han X, Yu J, Yang R, Huang G, Hoermann G, Tse W, Liu S

Cell death & disease · DOI 10.1038/s41419-025-08045-6 · PMID 41203598

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2025 Sep

Aberrant splicing of CHEK1 is a driver of megakaryocytic dysplasia in U2AF1(S34F) mutant myelodysplastic neoplasms

Zhang W, Li B, Liu J, Yan Y, Yang L, Qin T, Xu Z, Sun Q, Jia Y, Wang H, Huang G, Wang H, Shi L, Zhou J, Xiao Z

Leukemia · DOI 10.1038/s41375-025-02684-6 · PMID 40652060

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2025 Aug 1

Mitophagy's impacts on cancer and neurodegenerative diseases: implications for future therapies

Huang J, Pham VT, Fu S, Huang G, Liu YG, Zheng L

Journal of hematology & oncology · DOI 10.1186/s13045-025-01727-w · PMID 40750884

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2025 Jun

Super-resolution imaging informed scRNA sequencing analysis reveals the critical role of GDF15 in rejuvenating aged hematopoietic stem cells

Shi Z, Zhang X, Yang H, Zheng X, Niu M, Zhang Y, Yuan P, Wei W, Huang G, Fang R, Chen L

Blood science (Baltimore, Md.) · DOI 10.1097/BS9.0000000000000236 · PMID 40416726

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2025 May 30

Integrated Computational and Functional Screening Identifies G9a Inhibitors for SETD2-mutant Leukemia

Zhang Y (张亚), Xia M (夏梦芳), Yi Z (易真伊), Sui P (岁品品), He X (何旭东), Wang L (王丽萍), Chen Q (陈祺仪), Zhu HH (主鸿鹄), Huang G (黄刚), Wang QF (王前飞)

Genomics, proteomics & bioinformatics · DOI 10.1093/gpbjnl/qzaf035 · PMID 40300107

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2025 Apr 28

Epigenetic silencing of DNA sensing pathway by FOXM1 blocks stress ligand-dependent antitumor immunity and immune memory

Timilsina S, Huang JY, Abdelfattah N, Medina D, Singh D, Abdulsahib S, Subbarayalu P, Do TP, Venkata PP, Nirzhor S, Prochnau J, Bhandari M, Zheng S, Chen Y, Huang G, Mukherjee N, Hromas R, Sung P, Kaklamani V, Vadlamudi R, Zhang N, Rao MK

Nature communications · DOI 10.1038/s41467-025-59186-3 · PMID 40295473

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2025 Apr

Age-Dependent Bi-Phasic Dynamics of Ly49(+)CD8(+) Regulatory T Cell Population

Srinivasan S, Mishra S, Fan KK, Wang L, Im J, Segura C, Mukherjee N, Huang G, Rao M, Ma C, Zhang N

Aging cell · DOI 10.1111/acel.14461 · PMID 39696807

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2025 Apr

CD133-Guided RNA Nanoparticle Delivery of FTO siRNA Impairs Leukemia Resistance to Tyrosine Kinase Inhibitor Therapy

Bian H, Zhou C, Koyama H, Gao W, Bian S, Cheng T, Han X, Tse W, Miron A, Liu S

RNA nanomed · DOI 10.59566/isrnn.2025.0201e · PMID 42004278

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2025 Jan 21

Sexual dimorphism in the mouse bone marrow niche regulates hematopoietic engraftment via sex-specific Kdm5c/Cxcl12 signaling

Cui X, Hou L, Yan B, Liu J, Zhang C, Sui P, Tong S, Luchsinger L, Mendelson A, Zhou D, Yang FC, Zhong H, Liang Y

The Journal of clinical investigation · DOI 10.1172/JCI182125 · PMID 39836478

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2025 Jan 9

Loss of Cpt1a results in elevated glucose-fueled mitochondrial oxidative phosphorylation and defective hematopoietic stem cells

Li J, Bai J, Pham VT, Hashimoto M, Sezaki M, Shi Q, Jin Q, He C, Armstrong A, Li T, Pan M, Liu S, Luan Y, Zeng H, Andreassen PR, Huang G

The Journal of clinical investigation · DOI 10.1172/JCI184069 · PMID 39786963

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2024 Dec 4

The development and application of chimeric antigen receptor natural killer (CAR-NK) cells for cancer therapy: current state, challenges and emerging therapeutic advances

Yao P, Liu YG, Huang G, Hao L, Wang R

Experimental hematology & oncology · DOI 10.1186/s40164-024-00583-7 · PMID 39633491

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2024 Sep 27

The Laws of Attraction: Chemokines as Critical Mediators in Cancer Progression and Immunotherapy Response in Bladder Cancer

Hassouneh Z, Kim ME, Bowman N, Rao M, Zhang N, Huang G, Svatek RS, Mukherjee N

Cancers · DOI 10.3390/cancers16193303 · PMID 39409924

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2024 May

Long-term benefits of hematopoietic stem cell-based macrophage/microglia delivery of GDNF to the CNS in a mouse model of Parkinson's disease

Ge G, Sivasubramanian BP, Geng BD, Zhao S, Zhou Q, Huang G, O'Connor JC, Clark RA, Li S

Gene therapy · DOI 10.1038/s41434-024-00451-3 · PMID 38627469

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2024 Feb 22

Ectopic expression of the transcription factor ONECUT3 drives a complex karyotype in myelodysplastic syndromes

Luo Y, Feng X, Lang W, Xu W, Wang W, Mei C, Ye L, Zhu S, Wang L, Zhou X, Zeng H, Ma L, Ren Y, Jin J, Xu R, Huang G, Tong H

The Journal of clinical investigation · DOI 10.1172/JCI172468 · PMID 38386414

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2024

Into the storm: the imbalance in the yin-yang immune response as the commonality of cytokine storm syndromes

Armstrong A, Tang Y, Mukherjee N, Zhang N, Huang G

Frontiers in immunology · DOI 10.3389/fimmu.2024.1448201 · PMID 39318634

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2023 Aug 10

Food for thought (and CML survival)

Sezaki M, Huang G

Blood · DOI 10.1182/blood.2023021051 · PMID 37561542

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2023 Jul 3

Exposure to microbial products followed by loss of Tet2 promotes myelodysplastic syndrome via remodeling HSCs

Yokomizo-Nakano T, Hamashima A, Kubota S, Bai J, Sorin S, Sun Y, Kikuchi K, Iimori M, Morii M, Kanai A, Iwama A, Huang G, Kurotaki D, Takizawa H, Matsui H, Sashida G

The Journal of experimental medicine · DOI 10.1084/jem.20220962 · PMID 37071125

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2023 Jun 13

A critical role of RUNX1 in governing megakaryocyte-primed hematopoietic stem cell differentiation

Wang C, Tu Z, Cai X, Wang W, Davis AK, Nattamai K, Paranjpe A, Dexheimer P, Wu J, Huang FL, Geiger H, Huang G, Zheng Y

Blood advances · DOI 10.1182/bloodadvances.2022008591 · PMID 36661340

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2023 Mar

Runx1/3-driven adaptive endoplasmic reticulum stress pathways contribute to neurofibromagenesis

Na Y, Hall A, Yu Y, Hu L, Choi K, Burgard JA, Szabo S, Huang G, Ratner N, Wu J

Oncogene · DOI 10.1038/s41388-023-02620-x · PMID 36759572

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2023 Jan 11

Repurposing immunosuppressants for antileukemia therapy

Sezaki M, Huang G

EMBO molecular medicine · DOI 10.15252/emmm.202217042 · PMID 36453114

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