Publications

2009 Oct 1

The p53 tumor suppressor protein is a critical regulator of hematopoietic stem cell behavior

Liu Y, Elf SE, Asai T, Miyata Y, Liu Y, Sashida G, Huang G, Di Giandomenico S, Koff A, Nimer SD

Cell cycle (Georgetown, Tex.) · DOI 10.4161/cc.8.19.9627 · PMID 19755852

2009 Jan 9

p53 regulates hematopoietic stem cell quiescence

Liu Y, Elf SE, Miyata Y, Sashida G, Liu Y, Huang G, Di Giandomenico S, Lee JM, Deblasio A, Menendez S, Antipin J, Reva B, Koff A, Nimer SD

Cell stem cell · DOI 10.1016/j.stem.2008.11.006 · PMID 19128791

2008 Sep

Genetic evidence of PEBP2beta-independent activation of Runx1 in the murine embryo

Yokomizo T, Yanagida M, Huang G, Osato M, Honda C, Ema M, Takahashi S, Yamamoto M, Ito Y

International journal of hematology · DOI 10.1007/s12185-008-0121-4 · PMID 18594778

2008 Aug 1

PU.1 expression is modulated by the balance of functional sense and antisense RNAs regulated by a shared cis-regulatory element

Ebralidze AK, Guibal FC, Steidl U, Zhang P, Lee S, Bartholdy B, Jorda MA, Petkova V, Rosenbauer F, Huang G, Dayaram T, Klupp J, O'Brien KB, Will B, Hoogenkamp M, Borden KL, Bonifer C, Tenen DG

Genes & development · DOI 10.1101/gad.1654808 · PMID 18676813

2008 Mar 1

Methylation of RUNX1 by PRMT1 abrogates SIN3A binding and potentiates its transcriptional activity

Zhao X, Jankovic V, Gural A, Huang G, Pardanani A, Menendez S, Zhang J, Dunne R, Xiao A, Erdjument-Bromage H, Allis CD, Tempst P, Nimer SD

Genes & development · DOI 10.1101/gad.1632608 · PMID 18316480

2008 Jan

PU.1 is a major downstream target of AML1 (RUNX1) in adult mouse hematopoiesis

Huang G, Zhang P, Hirai H, Elf S, Yan X, Chen Z, Koschmieder S, Okuno Y, Dayaram T, Growney JD, Shivdasani RA, Gilliland DG, Speck NA, Nimer SD, Tenen DG

Nature genetics · DOI 10.1038/ng.2007.7 · PMID 17994017

2007 Nov

The Pu.1 locus is differentially regulated at the level of chromatin structure and noncoding transcription by alternate mechanisms at distinct developmental stages of hematopoiesis

Hoogenkamp M, Krysinska H, Ingram R, Huang G, Barlow R, Clarke D, Ebralidze A, Zhang P, Tagoh H, Cockerill PN, Tenen DG, Bonifer C

Molecular and cellular biology · DOI 10.1128/MCB.00905-07 · PMID 17785440

2005 Apr

Potential autoregulation of transcription factor PU.1 by an upstream regulatory element

Okuno Y, Huang G, Rosenbauer F, Evans EK, Radomska HS, Iwasaki H, Akashi K, Moreau-Gachelin F, Li Y, Zhang P, Göttgens B, Tenen DG

Molecular and cellular biology · DOI 10.1128/MCB.25.7.2832-2845.2005 · PMID 15767686

2004 Apr 15

Molecular basis for a dominant inactivation of RUNX1/AML1 by the leukemogenic inversion 16 chimera

Huang G, Shigesada K, Wee HJ, Liu PP, Osato M, Ito Y

Blood · DOI 10.1182/blood-2003-07-2188 · PMID 15070703

2002 Oct

Serine phosphorylation of RUNX2 with novel potential functions as negative regulatory mechanisms

Wee HJ, Huang G, Shigesada K, Ito Y

EMBO reports · DOI 10.1093/embo-reports/kvf193 · PMID 12231506

2001 Feb 15

Dimerization with PEBP2beta protects RUNX1/AML1 from ubiquitin-proteasome-mediated degradation

Huang G, Shigesada K, Ito K, Wee HJ, Yokomizo T, Ito Y

The EMBO journal · DOI 10.1093/emboj/20.4.723 · PMID 11179217

2000 Sep 12

A RUNX2/PEBP2alpha A/CBFA1 mutation displaying impaired transactivation and Smad interaction in cleidocranial dysplasia

Zhang YW, Yasui N, Ito K, Huang G, Fujii M, Hanai J, Nogami H, Ochi T, Miyazono K, Ito Y

Proceedings of the National Academy of Sciences of the United States of America · DOI 10.1073/pnas.180309597 · PMID 10962029

1999 Jul 15

Block of granulocytic differentiation of 32Dcl3 cells by AML1/ETO(MTG8) but not by highly expressed Bcl-2

Kohzaki H, Ito K, Huang G, Wee HJ, Murakami Y, Ito Y

Oncogene · DOI 10.1038/sj.onc.1202735 · PMID 10435586

1998 Feb 17

Negative regulation of granulocytic differentiation in the myeloid precursor cell line 32Dcl3 by ear-2, a mammalian homolog of Drosophila seven-up, and a chimeric leukemogenic gene, AML1/ETO

Ahn MY, Huang G, Bae SC, Wee HJ, Kim WY, Ito Y

Proceedings of the National Academy of Sciences of the United States of America · DOI 10.1073/pnas.95.4.1812 · PMID 9465099

1997 Jul

A novel transcript encoding an N-terminally truncated AML1/PEBP2 alphaB protein interferes with transactivation and blocks granulocytic differentiation of 32Dcl3 myeloid cells

Zhang YW, Bae SC, Huang G, Fu YX, Lu J, Ahn MY, Kanno Y, Kanno T, Ito Y

Molecular and cellular biology · DOI 10.1128/MCB.17.7.4133 · PMID 9199349

A Critical Role of RUNX1 in Governing Megakaryocyte-Primed Hematopoietic Stem Cell Differentiation

Blood advances