2015
Runx1: a new driver in neurofibromagenesis
Wu J, Huang G, Ratner N
Oncoscience · DOI 10.18632/oncoscience.266 · PMID 26697518
Publications
Publications
Browse recent publications with filters for title, author, journal, and year.
2014 Nov
Cytogenetic studies and their prognostic contribution in 565 Chinese patients with primary myelofibrosis
Li B, Xu J, Li C, Gale RP, Xu Z, Qin T, Zhang Y, Huang G, Fang L, Zhang H, Pan L, Hu N, Qu S, Xiao Z
American journal of hematology · DOI 10.1002/ajh.23824 · PMID 25132428
2014 Oct 9
The Runx-PU.1 pathway preserves normal and AML/ETO9a leukemic stem cells
Staber PB, Zhang P, Ye M, Welner RS, Levantini E, Di Ruscio A, Ebralidze AK, Bach C, Zhang H, Zhang J, Vanura K, Delwel R, Yang H, Huang G, Tenen DG
Blood · DOI 10.1182/blood-2014-01-550855 · PMID 25185713
2014 Jul
PU.1 is essential for MLL leukemia partially via crosstalk with the MEIS/HOX pathway
Zhou J, Wu J, Li B, Liu D, Yu J, Yan X, Zheng S, Wang J, Zhang L, Zhang L, He F, Li Q, Chen A, Zhang Y, Zhao X, Guan Y, Zhao X, Yan J, Ni J, Nobrega MA, Löwenberg B, Delwel R, Valk PJ, Kumar A, Xie L, Tenen DG, Huang G, Wang QF
Leukemia · DOI 10.1038/leu.2013.384 · PMID 24445817
2014 Jun 23
Ezh2 loss promotes development of myelodysplastic syndrome but attenuates its predisposition to leukaemic transformation
Sashida G, Harada H, Matsui H, Oshima M, Yui M, Harada Y, Tanaka S, Mochizuki-Kashio M, Wang C, Saraya A, Muto T, Hayashi Y, Suzuki K, Nakajima H, Inaba T, Koseki H, Huang G, Kitamura T, Iwama A
Nature communications · DOI 10.1038/ncomms5177 · PMID 24953053
2014 May
Serum iron metabolism and erythropoiesis in patients with myelodysplastic syndrome not receiving RBC transfusions
Cui R, Gale RP, Zhu G, Xu Z, Qin T, Zhang Y, Huang G, Li B, Fang L, Zhang H, Pan L, Hu N, Qu S, Xiao Z
Leukemia research · DOI 10.1016/j.leukres.2014.01.016 · PMID 24598841
2014 Mar 13
Downregulation of RUNX1/CBFβ by MLL fusion proteins enhances hematopoietic stem cell self-renewal
Zhao X, Chen A, Yan X, Zhang Y, He F, Hayashi Y, Dong Y, Rao Y, Li B, Conway RM, Maiques-Diaz A, Elf SE, Huang N, Zuber J, Xiao Z, Tse W, Tenen DG, Wang Q, Chen W, Mulloy JC, Nimer SD, Huang G
Blood · DOI 10.1182/blood-2013-03-489575 · PMID 24449215
2014 Mar
Identification of functional cooperative mutations of SETD2 in human acute leukemia
Zhu X, He F, Zeng H, Ling S, Chen A, Wang Y, Yan X, Wei W, Pang Y, Cheng H, Hua C, Zhang Y, Yang X, Lu X, Cao L, Hao L, Dong L, Zou W, Wu J, Li X, Zheng S, Yan J, Zhou J, Zhang L, Mi S, Wang X, Zhang L, Zou Y, Chen Y, Geng Z, Wang J, Zhou J, Liu X, Wang J, Yuan W, Huang G, Cheng T, Wang QF
Nature genetics · DOI 10.1038/ng.2894 · PMID 24509477
2013 Oct
A SALL4/MLL/HOXA9 pathway in murine and human myeloid leukemogenesis
Li A, Yang Y, Gao C, Lu J, Jeong HW, Liu BH, Tang P, Yao X, Neuberg D, Huang G, Tenen DG, Chai L
The Journal of clinical investigation · DOI 10.1172/JCI62891 · PMID 24051379
2013 Sep
RUNX1 meets MLL: epigenetic regulation of hematopoiesis by two leukemia genes
Koh CP, Wang CQ, Ng CE, Ito Y, Araki M, Tergaonkar V, Huang G, Osato M
Leukemia · DOI 10.1038/leu.2013.200 · PMID 23817177
2013 Sep
Transcription factor RUNX1 promotes survival of acute myeloid leukemia cells
Goyama S, Schibler J, Cunningham L, Zhang Y, Rao Y, Nishimoto N, Nakagawa M, Olsson A, Wunderlich M, Link KA, Mizukawa B, Grimes HL, Kurokawa M, Liu PP, Huang G, Mulloy JC
The Journal of clinical investigation · DOI 10.1172/JCI68557 · PMID 23979164
2013 May 30
PU.1 level-directed chromatin structure remodeling at the Irf8 gene drives dendritic cell commitment
Schönheit J, Kuhl C, Gebhardt ML, Klett FF, Riemke P, Scheller M, Huang G, Naumann R, Leutz A, Stocking C, Priller J, Andrade-Navarro MA, Rosenbauer F
Cell reports · DOI 10.1016/j.celrep.2013.04.007 · PMID 23623495
2013 Apr
Creation of a six-fingered artificial transcription factor that represses the hepatitis B virus HBx gene integrated into a human hepatocellular carcinoma cell line
Zhao X, Zhao Z, Guo J, Huang P, Zhu X, Zhou X, Yang Z, Zhao L, Xu L, Xu J, Fu L, Zhang J, Zhang X, Dong Y, Huang G, Wang Q, Li B, Song X, Yang X, Liu S, Yi S, Yu T, Yu C, Hou L, Li J, Chen W
Journal of biomolecular screening · DOI 10.1177/1087057112463066 · PMID 23042077
2013 Mar 7
Sustained PU.1 levels balance cell-cycle regulators to prevent exhaustion of adult hematopoietic stem cells
Staber PB, Zhang P, Ye M, Welner RS, Nombela-Arrieta C, Bach C, Kerenyi M, Bartholdy BA, Zhang H, Alberich-Jordà M, Lee S, Yang H, Ng F, Zhang J, Leddin M, Silberstein LE, Hoefler G, Orkin SH, Göttgens B, Rosenbauer F, Huang G, Tenen DG
Molecular cell · DOI 10.1016/j.molcel.2013.01.007 · PMID 23395001
2013
Cyclic AMP responsive element binding proteins are involved in 'emergency' granulopoiesis through the upregulation of CCAAT/enhancer binding protein β
Hirai H, Kamio N, Huang G, Matsusue A, Ogino S, Kimura N, Satake S, Ashihara E, Imanishi J, Tenen DG, Maekawa T
PloS one · DOI 10.1371/journal.pone.0054862 · PMID 23382991
2012 Oct
Disordered epigenetic regulation in MLL-related leukemia
Zhang Y, Chen A, Yan XM, Huang G
International journal of hematology · DOI 10.1007/s12185-012-1180-0 · PMID 23054645
2012 Aug 2
Mll partial tandem duplication and Flt3 internal tandem duplication in a double knock-in mouse recapitulates features of counterpart human acute myeloid leukemias
Zorko NA, Bernot KM, Whitman SP, Siebenaler RF, Ahmed EH, Marcucci GG, Yanes DA, McConnell KK, Mao C, Kalu C, Zhang X, Jarjoura D, Dorrance AM, Heerema NA, Lee BH, Huang G, Marcucci G, Caligiuri MA
Blood · DOI 10.1182/blood-2012-03-415067 · PMID 22674806
2012 Aug 2
Stress hematopoiesis reveals abnormal control of self-renewal, lineage bias, and myeloid differentiation in Mll partial tandem duplication (Mll-PTD) hematopoietic stem/progenitor cells
Zhang Y, Yan X, Sashida G, Zhao X, Rao Y, Goyama S, Whitman SP, Zorko N, Bernot K, Conway RM, Witte D, Wang QF, Tenen DG, Xiao Z, Marcucci G, Mulloy JC, Grimes HL, Caligiuri MA, Huang G
Blood · DOI 10.1182/blood-2012-02-412379 · PMID 22740449
2011 Dec 15
The ability of MLL to bind RUNX1 and methylate H3K4 at PU.1 regulatory regions is impaired by MDS/AML-associated RUNX1/AML1 mutations
Huang G, Zhao X, Wang L, Elf S, Xu H, Zhao X, Sashida G, Zhang Y, Liu Y, Lee J, Menendez S, Yang Y, Yan X, Zhang P, Tenen DG, Osato M, Hsieh JJ, Nimer SD
Blood · DOI 10.1182/blood-2010-11-317909 · PMID 22012064
2011 Aug 26
RUNX1 regulates the CD34 gene in haematopoietic stem cells by mediating interactions with a distal regulatory element
Levantini E, Lee S, Radomska HS, Hetherington CJ, Alberich-Jorda M, Amabile G, Zhang P, Gonzalez DA, Zhang J, Basseres DS, Wilson NK, Koschmieder S, Huang G, Zhang DE, Ebralidze AK, Bonifer C, Okuno Y, Gottgens B, Tenen DG
The EMBO journal · DOI 10.1038/emboj.2011.285 · PMID 21873977
2011 Aug 5
The leukemogenicity of AML1-ETO is dependent on site-specific lysine acetylation
Wang L, Gural A, Sun XJ, Zhao X, Perna F, Huang G, Hatlen MA, Vu L, Liu F, Xu H, Asai T, Xu H, Deblasio T, Menendez S, Voza F, Jiang Y, Cole PA, Zhang J, Melnick A, Roeder RG, Nimer SD
Science (New York, N.Y.) · DOI 10.1126/science.1201662 · PMID 21764752
2011 Jul 15
The mef/elf4 transcription factor fine tunes the DNA damage response
Sashida G, Bae N, Di Giandomenico S, Asai T, Gurvich N, Bazzoli E, Liu Y, Huang G, Zhao X, Menendez S, Nimer SD
Cancer research · DOI 10.1158/0008-5472.CAN-11-0455 · PMID 21616937
2011 Jun
MIR29B regulates expression of MLLT11 (AF1Q), an MLL fusion partner, and low MIR29B expression associates with adverse cytogenetics and poor overall survival in AML
Xiong Y, Li Z, Ji M, Tan AC, Bemis J, Tse JV, Huang G, Park J, Ji C, Chen J, Bemis LT, Bunting KD, Tse W
British journal of haematology · DOI 10.1111/j.1365-2141.2011.08662.x · PMID 21496004
2010 Jul
CARM1 is required for proper control of proliferation and differentiation of pulmonary epithelial cells
O'Brien KB, Alberich-Jordà M, Yadav N, Kocher O, Diruscio A, Ebralidze A, Levantini E, Sng NJ, Bhasin M, Caron T, Kim D, Steidl U, Huang G, Halmos B, Rodig SJ, Bedford MT, Tenen DG, Kobayashi S
Development (Cambridge, England) · DOI 10.1242/dev.037150 · PMID 20530543
2010 May 18
Accelerated leukemogenesis by truncated CBF beta-SMMHC defective in high-affinity binding with RUNX1
Kamikubo Y, Zhao L, Wunderlich M, Corpora T, Hyde RK, Paul TA, Kundu M, Garrett L, Compton S, Huang G, Wolff L, Ito Y, Bushweller J, Mulloy JC, Liu PP
Cancer cell · DOI 10.1016/j.ccr.2010.03.022 · PMID 20478528