2019 Nov
SETD2 mutations confer chemoresistance in acute myeloid leukemia partly through altered cell cycle checkpoints
Dong Y, Zhao X, Feng X, Zhou Y, Yan X, Zhang Y, Bu J, Zhan D, Hayashi Y, Zhang Y, Xu Z, Huang R, Wang J, Zhao T, Xiao Z, Ju Z, Andreassen PR, Wang QF, Chen W, Huang G
Leukemia · DOI 10.1038/s41375-019-0456-2 · PMID 30967619
2019 Oct
Deletion of a flippase subunit Tmem30a in hematopoietic cells impairs mouse fetal liver erythropoiesis
Yang F, Huang Y, Chen X, Liu L, Liao D, Zhang H, Huang G, Liu W, Zhu X, Wang W, Lobo CA, Yazdanbakhsh K, An X, Ju Z
Haematologica · DOI 10.3324/haematol.2018.203992 · PMID 30819915
2019 Oct
Using circulating tumor DNA to monitor myelodysplastic syndromes status
Zhao P, Qin J, Liu W, Zhu Q, Fan T, Xiao H, Wang J, Huang G, Xiaomei H
Hematological oncology · DOI 10.1002/hon.2649 · PMID 31291480
2019 Aug 1
Identification and transcriptome analysis of erythroblastic island macrophages
Li W, Wang Y, Zhao H, Zhang H, Xu Y, Wang S, Guo X, Huang Y, Zhang S, Han Y, Wu X, Rice CM, Huang G, Gallagher PG, Mendelson A, Yazdanbakhsh K, Liu J, Chen L, An X
Blood · DOI 10.1182/blood.2019000430 · PMID 31101625
2019 Jul
Prognostic impact of red blood cell distribution width in myelodysplastic syndromes
Shi Z, Li B, Huang H, Qin T, Xu Z, Zhang H, Fang L, Pan L, Hu N, Qu S, Huang G, Gale RP, Xiao Z
British journal of haematology · DOI 10.1111/bjh.15830 · PMID 30836422
2019 May
Hypoxia/pseudohypoxia-mediated activation of hypoxia-inducible factor-1α in cancer
Hayashi Y, Yokota A, Harada H, Huang G
Cancer science · DOI 10.1111/cas.13990 · PMID 30844107
2019 Apr
RUNX represses Pmp22 to drive neurofibromagenesis
Hall A, Choi K, Liu W, Rose J, Zhao C, Yu Y, Na Y, Cai Y, Coover RA, Lin Y, Dombi E, Kim M, Levanon D, Groner Y, Boscolo E, Pan D, Liu PP, Lu QR, Ratner N, Huang G, Wu J
Science advances · DOI 10.1126/sciadv.aau8389 · PMID 31032403
2019 Mar
Histone H3 trimethylation at lysine 36 guides m(6)A RNA modification co-transcriptionally
Huang H, Weng H, Zhou K, Wu T, Zhao BS, Sun M, Chen Z, Deng X, Xiao G, Auer F, Klemm L, Wu H, Zuo Z, Qin X, Dong Y, Zhou Y, Qin H, Tao S, Du J, Liu J, Lu Z, Yin H, Mesquita A, Yuan CL, Hu YC, Sun W, Su R, Dong L, Shen C, Li C, Qing Y, Jiang X, Wu X, Sun M, Guan JL, Qu L, Wei M, Müschen M, Huang G, He C, Yang J, Chen J
Nature · DOI 10.1038/s41586-019-1016-7 · PMID 30867593
2019 Mar
The high NRF2 expression confers chemotherapy resistance partly through up-regulated DUSP1 in myelodysplastic syndromes
Lin P, Ren Y, Yan X, Luo Y, Zhang H, Kesarwani M, Bu J, Zhan D, Zhou Y, Tang Y, Zhu S, Xu W, Zhou X, Mei C, Ma L, Ye L, Hu C, Azam M, Ding W, Jin J, Huang G, Tong H
Haematologica · DOI 10.3324/haematol.2018.197749 · PMID 30262569
2019 Feb
[Consistency Analysis of Gene Mutation Sites of Bone Marrow Tumor DNA and Circulating Tumor DNA in Patients with Myelodysplastic Syndrome]
Zhao P, Zhu QZ, Fan T, Liu WY, Xiao HY, Qin JY, Huang G, Hu XM
Zhongguo shi yan xue ye xue za zhi · DOI 10.7534/j.issn.1009-2137.2019.01.024 · PMID 30738462
2018 Dec 10
A Transcription Factor Addiction in Leukemia Imposed by the MLL Promoter Sequence
Lu B, Klingbeil O, Tarumoto Y, Somerville TDD, Huang YH, Wei Y, Wai DC, Low JKK, Milazzo JP, Wu XS, Cao Z, Yan X, Demerdash OE, Huang G, Mackay JP, Kinney JB, Shi J, Vakoc CR
Cancer cell · DOI 10.1016/j.ccell.2018.10.015 · PMID 30503706
2018 Dec
The usefulness of mutational data on prognosis of myelodysplastic syndromes: alone or incorporated into the IPSS-R?
Li B, Liu J, Xu Z, Qin T, Shi Z, Song Z, Huang H, Fang L, Zhang H, Pan L, Hu N, Qu S, Zhang Y, Huang G, Xiao Z
British journal of haematology · DOI 10.1111/bjh.15036 · PMID 29193004
2018 Nov
Pathobiological Pseudohypoxia as a Putative Mechanism Underlying Myelodysplastic Syndromes
Hayashi Y, Zhang Y, Yokota A, Yan X, Liu J, Choi K, Li B, Sashida G, Peng Y, Xu Z, Huang R, Zhang L, Freudiger GM, Wang J, Dong Y, Zhou Y, Wang J, Wu L, Bu J, Chen A, Zhao X, Sun X, Chetal K, Olsson A, Watanabe M, Romick-Rosendale LE, Harada H, Shih LY, Tse W, Bridges JP, Caligiuri MA, Huang T, Zheng Y, Witte DP, Wang QF, Qu CK, Salomonis N, Grimes HL, Nimer SD, Xiao Z, Huang G
Cancer discovery · DOI 10.1158/2159-8290.CD-17-1203 · PMID 30139811
2018 Oct 23
Defective transcription elongation in a subset of cancers confers immunotherapy resistance
Modur V, Singh N, Mohanty V, Chung E, Muhammad B, Choi K, Chen X, Chetal K, Ratner N, Salomonis N, Weirauch MT, Waltz S, Huang G, Privette-Vinnedge L, Park JS, Janssen EM, Komurov K
Nature communications · DOI 10.1038/s41467-018-06810-0 · PMID 30353012
2018 Oct
A novel fusion of PDGFRB to TSC1, an intrinsic suppressor of mTOR-signaling pathway, in a chronic eosinophilic leukemia patient with t(5;9)(q32;q34)
Zhang Y, Qu S, Wang Q, Li J, Xu Z, Qin T, Huang G, Xiao Z
Leukemia & lymphoma · DOI 10.1080/10428194.2018.1427855 · PMID 29384404
2018 Oct
Loss of YTHDF2-mediated m(6)A-dependent mRNA clearance facilitates hematopoietic stem cell regeneration
Wang H, Zuo H, Liu J, Wen F, Gao Y, Zhu X, Liu B, Xiao F, Wang W, Huang G, Shen B, Ju Z
Cell research · DOI 10.1038/s41422-018-0082-y · PMID 30150673
2018 Jul
Setd2 regulates quiescence and differentiation of adult hematopoietic stem cells by restricting RNA polymerase II elongation
Zhou Y, Yan X, Feng X, Bu J, Dong Y, Lin P, Hayashi Y, Huang R, Olsson A, Andreassen PR, Grimes HL, Wang QF, Cheng T, Xiao Z, Jin J, Huang G
Haematologica · DOI 10.3324/haematol.2018.187708 · PMID 29650642
2018 Apr
SETD2-mediated crosstalk between H3K36me3 and H3K79me2 in MLL-rearranged leukemia
Bu J, Chen A, Yan X, He F, Dong Y, Zhou Y, He J, Zhan D, Lin P, Hayashi Y, Sun Y, Zhang Y, Xiao Z, Grimes HL, Wang QF, Huang G
Leukemia · DOI 10.1038/leu.2017.339 · PMID 29249820
2018 Feb 12
SF3B1 deficiency impairs human erythropoiesis via activation of p53 pathway: implications for understanding of ineffective erythropoiesis in MDS
Huang Y, Hale J, Wang Y, Li W, Zhang S, Zhang J, Zhao H, Guo X, Liu J, Yan H, Yazdanbakhsh K, Huang G, Hillyer CD, Mohandas N, Chen L, Sun L, An X
Journal of hematology & oncology · DOI 10.1186/s13045-018-0558-8 · PMID 29433555
2018 Feb
Clinical features and biological implications of different U2AF1 mutation types in myelodysplastic syndromes
Li B, Liu J, Jia Y, Wang J, Xu Z, Qin T, Shi Z, Song Z, Peng S, Huang H, Fang L, Zhang H, Pan L, Hu N, Qu S, Zhang Y, Wu J, Liu N, Ru K, Huang G, Xiao Z
Genes, chromosomes & cancer · DOI 10.1002/gcc.22510 · PMID 29057546
2018 Feb
Integrated genomic analysis identifies deregulated JAK/STAT-MYC-biosynthesis axis in aggressive NK-cell leukemia
Huang L, Liu D, Wang N, Ling S, Tang Y, Wu J, Hao L, Luo H, Hu X, Sheng L, Zhu L, Wang D, Luo Y, Shang Z, Xiao M, Mao X, Zhou K, Cao L, Dong L, Zheng X, Sui P, He J, Mo S, Yan J, Ao Q, Qiu L, Zhou H, Liu Q, Zhang H, Li J, Jin J, Fu L, Zhao W, Chen J, Du X, Qing G, Liu H, Liu X, Huang G, Ma D, Zhou J, Wang QF
Cell research · DOI 10.1038/cr.2017.146 · PMID 29148541
2018 Feb
Whole exome sequencing identifies novel mutations of epigenetic regulators in chemorefractory pediatric acute myeloid leukemia
Zhan D, Zhang Y, Xiao P, Zheng X, Ruan M, Zhang J, Chen A, Zou Y, Chen Y, Huang G, Hu S, Wang QF, Zhu X
Leukemia research · DOI 10.1016/j.leukres.2017.12.001 · PMID 29253671
2018 Jan 15
Thalidomide plus prednisone with or without danazol therapy in myelofibrosis: a retrospective analysis of incidence and durability of anemia response
Luo X, Xu Z, Li B, Qin T, Zhang P, Zhang H, Fang L, Pan L, Hu N, Qu S, Zhang Y, Huang G, Peter Gale R, Xiao Z
Blood cancer journal · DOI 10.1038/s41408-017-0029-4 · PMID 29335406
2018 Jan
Expansion of EPOR-negative macrophages besides erythroblasts by elevated EPOR signaling in erythrocytosis mouse models
Wang J, Hayashi Y, Yokota A, Xu Z, Zhang Y, Huang R, Yan X, Liu H, Ma L, Azam M, Bridges JP, Cancelas JA, Kalfa TA, An X, Xiao Z, Huang G
Haematologica · DOI 10.3324/haematol.2017.172775 · PMID 29051279
2017 Dec 21
Aggressive NK-cell leukemia: clinical subtypes, molecular features, and treatment outcomes
Tang YT, Wang D, Luo H, Xiao M, Zhou HS, Liu D, Ling SP, Wang N, Hu XL, Luo Y, Mao X, Ao QL, Huang J, Zhang W, Sheng LS, Zhu LJ, Shang Z, Gao LL, Zhang PL, Zhou M, Zhou KG, Qiu LG, Liu QF, Zhang HY, Li JY, Jin J, Fu L, Zhao WL, Chen JP, Du X, Huang G, Wang QF, Zhou JF, Huang L
Blood cancer journal · DOI 10.1038/s41408-017-0021-z · PMID 29263371